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compound 21 11-(1-piperazinyl)-5h-dibenzo [b, e] [1, 4] diazepine abbreviated as c21  (Tocris)


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    Tocris compound 21 11-(1-piperazinyl)-5h-dibenzo [b, e] [1, 4] diazepine abbreviated as c21
    Compound 21 11 (1 Piperazinyl) 5h Dibenzo [B, E] [1, 4] Diazepine Abbreviated As C21, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound+21+c21/pm39842626-69-23-24?v=Tocris
    Average 90 stars, based on 1 article reviews
    compound 21 11-(1-piperazinyl)-5h-dibenzo [b, e] [1, 4] diazepine abbreviated as c21 - by Bioz Stars, 2026-07
    90/100 stars

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    (A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; <t>C21,</t> <t>compound</t> <t>21</t> (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.
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    compound 21 11-(1-piperazinyl)-5h-dibenzo [b, e] [1, 4] diazepine abbreviated as c21  (Tocris)
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    Tocris compound 21 11-(1-piperazinyl)-5h-dibenzo [b, e] [1, 4] diazepine abbreviated as c21
    (A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; <t>C21,</t> <t>compound</t> <t>21</t> (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.
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    (A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; <t>C21,</t> <t>compound</t> <t>21</t> (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.
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    (A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; <t>C21,</t> <t>compound</t> <t>21</t> (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.
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    (A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; C21, compound 21 (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.

    Journal: Cell reports

    Article Title: Genetic identification of mouse trigeminal afferents responsible for mechanical allodynia

    doi: 10.1016/j.celrep.2025.116803

    Figure Lengend Snippet: (A) Design of the experiment. CNO, clozapine-N-oxide (150 mg/kg); IP, intraperitoneal; V2, maxillary area; V, von Frey test. (B) The effects of chemogenetic silencing of brushing-activated TRAPed trigeminal ganglia (BA TG) neurons on punctate allodynia. t(6.3) = 6.07; * p < 0.05 in Dunnett post hoc test following two-way ANOVA. (C) In a separate cohort of mice, tamoxifen was administered but face brushing was not performed. CNO at 24 days did not produce analgesia. (D) Design of the experiment. W, nocifensive face wiping behaviors; C21, compound 21 (non-hydrolyzable analogue of clozapine-N-oxide; 1 mmol in 20 mL); V2, maxillary area. (E) Face wiping behaviors were quantified for 20 min following the injection of saline or C21 to V2 skin. t(34) = 2.8, * p < 0.05 in Sidak post hoc testing following two-way ANOVA. n = 5 in mCherry and 6 in hM3Dq. In (B), (C), and (E), the error bars indicate SEM.

    Article Snippet: Compound 21 dihydrochloride (C21) , Hello Bio , HB6124.

    Techniques: Injection, Saline